Fig. 1
MRI analysis of ASC-derived signals 48 h post-MCAo. a Representative T2*-weighted images show hypointense ASC-derived signals in animals representing the control group as well as the group treated with 5 × 104, 3 × 105, or 1 × 106 ASCs. b Differences in ΔCSI obtained 48 h post MCAo are shown for all treatment groups. Groups are controls (n = 8 for MCAo = 45 min; n = 9 for MCAo = 90 min), and animals treated with 5 × 104 ASCs (n = 7; all MCAo = 45 min), 3 × 105 ASCs (both n = 6 for MCAo 45 min and 90 min), and 1 × 106 ASCs (n = 4 for MCAo = 45 min; n = 3 for MCAo = 90 min). The median of each treatment group is indicated as a red dotted line. Each column represents one animal with mean ΔCSI obtained in seven brain slices per animal ± standard deviation. **p < 0.01 for control group vs. 1 × 106 and 5 × 104 ASC group, ***p < 0.001 for control group vs. 3 × 105 ASC group. ASC adipose tissue derived stem cell, ΔCSI difference in cell signal intensity, MCAo middle cerebral artery occlusion