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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: The effect of adipose tissue-derived stem cells in a middle cerebral artery occlusion stroke model depends on their engraftment rate

Fig. 3

T2* re-analysis and cell signal development. a Signal pattern changes within 9 days post MCAo in the infarct area (dotted line, image 1) and consequential hyperintense signals displaying tissue changes as shown by the ADC map (image 2) are presented. Resulting ambiguous T2*-weighted hypointense signals (image 3) were re-analysed, leaving specific ASC-derived hypointense voxels (image 4). b Differences in voxel number obtained 48 h and 9 days post MCAo are shown for all treatment groups. Groups were controls (n = 5; n = 1 for MCAo = 45 min; n = 4 for MCAo = 90 min), and animals treated with 5 × 104 ASCs (n = 7; all MCAo = 45 min), 3 × 105 ASCs (n = 7; n = 6 for MCAo = 45 min; n = 1 for MCAo = 90 min), and 1 × 106 ASCs (n = 2; all MCAo = 90 min). The median for each group is indicated as a red dotted line for voxel numbers obtained 48 h post MCAo and as a green dotted line for voxel numbers obtained 9 days post MCAo. Each pair of columns represents values of one animal and two MRI time points. **p < 0.01 for 3 × 105 ASC group vs. control group and 5 × 104 ASC group. ADC apparent diffusion coefficient, ASC adipose tissue - derived stem cell, MCAo middle cerebral artery occlusion

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