Fig. 2

Levels of CD14⁺⁺CD16⁺ monocytes in sepsis patients and their correlation with disease severity scores. a A representative flow cytometry plot showed the distribution of CD14⁺⁺CD16^–, CD14⁺⁺CD16⁺ and CD14⁺CD16⁺⁺ monocytes in healthy donors and sepsis patients. b The box and whisker plots represent the percentage of CD14⁺⁺CD16⁺, CD14⁺CD16⁺⁺, and CD14⁺⁺CD16^– monocytes in the total monocyte population of healthy donors (n = 25) and sepsis patients (n = 23). The plot shows a median (lines within boxes), interquartile range (bounds of boxes), and error bars (upper and lower ranges). c There was a positive correlation between CD14⁺⁺CD16⁺ expression and the Acute Physiology and Chronic Health Evaluation II (APACHE II) score (n = 23, Spearman’s correlation coefficient r = 0.512, p < 0.05). There was also a positive correlation between CD14⁺⁺CD16⁺ expression and the Sequential Organ Failure Assessment (SOFA) score (n = 23, r = 0.439, p < 0.05). Linear curves represent least-squares lines. ***p < 0.001