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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway

Fig. 4

Histological features and expression of α-SMA of the rabbit ear wounds in each group. a, b Skin tissue sections stained with H&E and Masson showing histological features in rabbit ears treated with saline (control), bFGF, bFGF + DAPT, and TGF-β1 on post-injury days 7, 14, 30, and 60. bFGF-treated ears exhibited significantly higher quality wound healing, with more cell layers, more epidermal ridges, more formation of primitive hair follicle and sweat gland structures, and more regular and ordered collagen arrangement. Ears treated with bFGF + DAPT and TGF-β1 exhibited poor-quality wound healing compared with control ears. c Immunohistochemical staining for α-SMA was performed using skin tissue sections in rabbit ears treated with saline (control), bFGF, bFGF + DAPT, and TGF-β1 on post-injury days 7, 14, 30, and 60. bFGF-treated ears exhibited a significantly higher quality wound healing with a significant decrease of α-SMA, while ears treated with bFGF + DAPT and TGF-β1 exhibited poor-quality wound healing with increase of α-SMA. Scale bar, 100 μm. d days, bFGF basic fibroblast growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512