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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Immunosuppressive capacity of mesenchymal stem cells correlates with metabolic activity and can be enhanced by valproic acid

Fig. 1

MSC-induced T-cell suppression depends on MSC and T-cell donors. Proliferation of CFSE-labeled CD4+ as well as CD8+ T-cell subpopulations was induced with CD3/28 antibodies and the CFSE intensity was measured via flow cytometry. The exemplary result of one representative experiment is shown (n = 1). a PBMCs from three different donors were cocultured with MSCs from one batch. T-cells responded differently to MSC-mediated suppression. b PBMCs from one donor were cocultured with MSCs from four different batches. Extent of T-cell suppression varied distinctly between different MSC batches. CFSE carboxyfluorescein succinimidyl ester, MSC mesenchymal stem cell

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