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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Immunosuppressive capacity of mesenchymal stem cells correlates with metabolic activity and can be enhanced by valproic acid

Fig. 2

Immunosuppressive capacity of MSCs correlates with glycolytic and respiratory activity. MSCs were cocultured with PBMCs from different donors and subjected to T-cell proliferation assays as well as metabolic measurements simultaneously. PBMC-dependent increase of a ECAR and b OCR of MSCs after 24 h of coculture with two different PBMC donors (donor A and donor B) in comparison with MSCs in monoculture (n = 1 in sixfold repetition). ECAR and OCR of PBMCs in monoculture were measured as a control. c ECAR and d OCR of MSCs correlate with their T-cell suppressive capacity (n = 9). ECAR extracellular acidification rate, MSC mesenchymal stem cell, OCR oxygen consumption rate, PBMC peripheral blood mononuclear cell, r Pearson’s r value. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001

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