Fig. 2From: Immunosuppressive capacity of mesenchymal stem cells correlates with metabolic activity and can be enhanced by valproic acidImmunosuppressive capacity of MSCs correlates with glycolytic and respiratory activity. MSCs were cocultured with PBMCs from different donors and subjected to T-cell proliferation assays as well as metabolic measurements simultaneously. PBMC-dependent increase of a ECAR and b OCR of MSCs after 24 h of coculture with two different PBMC donors (donor A and donor B) in comparison with MSCs in monoculture (n = 1 in sixfold repetition). ECAR and OCR of PBMCs in monoculture were measured as a control. c ECAR and d OCR of MSCs correlate with their T-cell suppressive capacity (n = 9). ECAR extracellular acidification rate, MSC mesenchymal stem cell, OCR oxygen consumption rate, PBMC peripheral blood mononuclear cell, r Pearson’s r value. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001Back to article page