Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Differential expression of cell cycle and WNT pathway-related genes accounts for differences in the growth and differentiation potential of Wharton’s jelly and bone marrow-derived mesenchymal stem cells

Fig. 3

Cell cycle analysis and relative expression of cell cycle-related genes in WJ-MSCs compared to BM-MSCs. a BM- and WJ-MSCs from P2, at a confluency of 80–90% were stained by propodium iodide and subsequently cell cycle distribution was analyzed by flow cytometry. Bars represent the proportion of cells in each phase of the cell cycle and the values shown are the means ± 1 standard deviation of n = 18 independent experiments. b The columns represent the mean fold change in the expression of genes related to cell cycle in WJ-MSCs (n = 6) at P2, compared to the respective BM-MSCs (n = 6), using a real-time PCR array. The fold change for each gene between the group of WJ-MSCs and the group of BM-MSCs was calculated with the ΔΔCt method and only genes exhibiting at least a two-fold change are depicted. Differentially expressed genes have been grouped according to their implication in specific cellular process such as spindle regulation, cell cycle regulation, cell proliferation, apoptosis and DNA damage response. Abbreviations: BM-MSCs bone marrow-mesenchymal stem cells, P passage, WJ-MSCs Wharton’s jelly-mesenchymal stem cells

Back to article page