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Table 2 Cytokines in MSC culture supernatants

From: Differential expression of cell cycle and WNT pathway-related genes accounts for differences in the growth and differentiation potential of Wharton’s jelly and bone marrow-derived mesenchymal stem cells

Cytokinesa

WJ-MSC culture supernatants

(n = 18)

BM-MSC culture supernatants

(n = 18)

 

P2

P6

P10

P2

P6

P10

P value

FLT3L (ng/mL)

13.79 ± 0.75

14.35 ± 1.24

13.74 ± 0.87

13.77 ± 0.96

14.70 ± 6 2.33

13.43 ± 0.45

N.S.

SDF1-α (ng/mL)

1189.00 ± 380.40

1159.00 ± 401.00

1032.00 ± 269.00

2074.00 ± 1247.00

1607.00 ± 698.00

1369.00 ± 420.60

0.0012

G-CSF (ng/mL)

108.30 ± 100.70

578.00 ± 409.80

388.00 ± 360.00

N.D.

N.D.

N.D

<0.0001

GM-CSF (ng/mL)

12.19 ± 9.46

145.20 ± 135.60

37.70 ± 13.58

N.D.

N.D.

N.D.

0.0002

  1. Cytokine measurements have been performed by means of an enzyme-linked immunosorbent assay (ELISA). Comparisons in cytokine levels between WJ-MSCs and BM-MSC supernatants through passages (P) P2-P6-P10, were performed by two-way analysis of variance and the statistically significant P values are shown
  2. Abbreviations: WJ-MSCs Wharton’s jelly-mesenchymal stem cells, BM-MSCs bone marrow-derived mesenchymal stem cells, P passage, FLT3L FMS-like tyrosine kinase 3 ligand, SDF-1α stromal cell-derived factor-1α, G-CSF granulocyte colony-stimulating factor, GM-CSF granulocyte-macrophage colony -stimulating factor, N.S. no statistically significant difference, N.D. not detected
  3. aThe data are expressed as means ± 1 standard deviation