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Table 3 Laboratory parameters at baseline and 12-month follow-up

From: Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients

Patient parameters

Normal range

Baseline (Mean ± SD)

12-month (Mean ± SD)

Difference (Mean ± SD)

P value (Paired t test)

Leukocytes (/ul)

4000–10000

5700 ± 885.4

6468.3 ± 2153.2

768.3 ± 1406.9

0.24

Hemoglobin (g/dl)

12–16

12.8 ± 1.7

13 ± 1.2

0.2 ± 0.8

0.55

HCT (%)

38–47

37.4 ± 3.8

39.5 ± 3.4

2.1 ± 2.9

0.15

MCV (fl)

80–96

88.8 ± 9.4

89.5 ± 3.3

0.7 ± 7.8

0.82

Platelets (*103/ul)

150–450

211.7 ± 56.8

187.3 ± 42

-24.3 ± 46

0.25

FBS (mg/dl)

60–105

96.8 ± 10

87.4 ± 11.9

-6.2 ± 7.2

0.13

HbA1c (%)

4–6

5.2 ± 0.3

5.1 ± 0.40

0 ± 0.1

0.3

Sodium (mEq/l)

134–148

141.8 ± 1.9

141.3 ± 2

-0.5 ± 1.2

0.36

Potassium (mEq/l)

3.5–5.5

4.4 ± 0.5

4.3 ± 0.5

-0.1 ± 0.4

0.41

Calcium (mg/dl)

8.6–10

9.3 ± 0.6

9.4 ± 0.3

0 ± 0.8

0.79

Phosphorus (mg/dl)

2.6–4.5

3.7 ± 0.6

3.7 ± 0.5

0 ± 0.5

0.89

TSH (MIU/ml)

0.2–5.0

2.3 ± 1.1

2.4 ± 1.3

0.1 ± 1.7

0.86

PTH (pg/ml)

15–65

140.3 ± 71

112 ± 48.3

-29.2 ± 55.2

0.25

ESR 1 h (mm/h)

3–20

22.2 ± 18.8

15.5 ± 10.3

-6.7 ± 9.9

0.16

CRP (mg/l)

0–10

5.1 ± 8.7

0.3 ± 0.9

-4.7 ± 8.5

0.23

Albumin (g/dl)

3.5–5.2

4.3 ± 0.3

4.4 ± 0.5

0.1 ± 0.6

0.68

Uric acid (mg/l)

2.6–6

6.5 ± 2.1

7.2 ± 1.3

0.7 ± 1.7

0.38

ALT(U/l)

0–40

24.3 ± 9.8

19.3 ± 6.6

-5.0 ± 11.5

0.34

AST (U/l)

0–31

29.7 ± 18.5

20.5 ± 5.8

-9.1 ± 17.4

0.25

Alkaline phosphatase (U/l)

0–240

231.2 ± 62.5

155.8 ± 53.8

-75.3 ± 83.9

0.07

Total cholesterol (mg/dl)

<200 desirable

177 ± 44.2

172.5 ± 42

-4.5 ± 23.7

0.66

Triglycerides (mg/dl)

<200 desirable

191.7 ± 150.7

192.5 ± 108.2

0.8 ± 62.8

0.97

LDL cholesterol (mg/dl)

<100 low risk

99.5 ± 34

96 ± 30.2

-3.5 ± 18.8

0.67

HDL cholesterol (mg/dl)

>55 no risk

39.2 ± 11

41.3 ± 12.3

2.2 ± 9.8

0.61

Dipstick proteinuriaa

Negative

1.7 ± 0.8

1.3 ± 0.5

-0.3 ± 1

0.46

  1. ul microliter, g/dl grams per deciliter, HCT hematocrit, MCV mean corpuscular volume, fl femtoliters, FBS fasting blood sugar, HbA1c hemoglobin A1c, mg/dl milligram per deciliter, mEq/l milliequivalents per liter, TSH thyroid-stimulating hormone, MIU/ml milli-international units per milliliter, PTH parathyroid hormone, pg/ml pictogram per milliliter, ESR erythrocyte sedimentation rate, mm/h millimeters per hour, CRP C-reactive protein, mg/l milligram per liter, ALT alanine aminotransferase, U/lit units per liter, AST aspartate aminotransferase, LDL low-density lipoprotein, HDL high-density lipoprotein
  2. a Negative or 1 = 0 mg/dl; 2 = 15–30 mg/dl; 3 = 30–100 mg/dl; 4 = 100–300 mg/d; 5 = 300–1000 mg/dl; 6 > 1000 mg/dl
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Stem Cell Research & Therapy

ISSN: 1757-6512