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Table 3 Laboratory parameters at baseline and 12-month follow-up

From: Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients

Patient parameters Normal range Baseline (Mean ± SD) 12-month (Mean ± SD) Difference (Mean ± SD) P value (Paired t test)
Leukocytes (/ul) 4000–10000 5700 ± 885.4 6468.3 ± 2153.2 768.3 ± 1406.9 0.24
Hemoglobin (g/dl) 12–16 12.8 ± 1.7 13 ± 1.2 0.2 ± 0.8 0.55
HCT (%) 38–47 37.4 ± 3.8 39.5 ± 3.4 2.1 ± 2.9 0.15
MCV (fl) 80–96 88.8 ± 9.4 89.5 ± 3.3 0.7 ± 7.8 0.82
Platelets (*103/ul) 150–450 211.7 ± 56.8 187.3 ± 42 -24.3 ± 46 0.25
FBS (mg/dl) 60–105 96.8 ± 10 87.4 ± 11.9 -6.2 ± 7.2 0.13
HbA1c (%) 4–6 5.2 ± 0.3 5.1 ± 0.40 0 ± 0.1 0.3
Sodium (mEq/l) 134–148 141.8 ± 1.9 141.3 ± 2 -0.5 ± 1.2 0.36
Potassium (mEq/l) 3.5–5.5 4.4 ± 0.5 4.3 ± 0.5 -0.1 ± 0.4 0.41
Calcium (mg/dl) 8.6–10 9.3 ± 0.6 9.4 ± 0.3 0 ± 0.8 0.79
Phosphorus (mg/dl) 2.6–4.5 3.7 ± 0.6 3.7 ± 0.5 0 ± 0.5 0.89
TSH (MIU/ml) 0.2–5.0 2.3 ± 1.1 2.4 ± 1.3 0.1 ± 1.7 0.86
PTH (pg/ml) 15–65 140.3 ± 71 112 ± 48.3 -29.2 ± 55.2 0.25
ESR 1 h (mm/h) 3–20 22.2 ± 18.8 15.5 ± 10.3 -6.7 ± 9.9 0.16
CRP (mg/l) 0–10 5.1 ± 8.7 0.3 ± 0.9 -4.7 ± 8.5 0.23
Albumin (g/dl) 3.5–5.2 4.3 ± 0.3 4.4 ± 0.5 0.1 ± 0.6 0.68
Uric acid (mg/l) 2.6–6 6.5 ± 2.1 7.2 ± 1.3 0.7 ± 1.7 0.38
ALT(U/l) 0–40 24.3 ± 9.8 19.3 ± 6.6 -5.0 ± 11.5 0.34
AST (U/l) 0–31 29.7 ± 18.5 20.5 ± 5.8 -9.1 ± 17.4 0.25
Alkaline phosphatase (U/l) 0–240 231.2 ± 62.5 155.8 ± 53.8 -75.3 ± 83.9 0.07
Total cholesterol (mg/dl) <200 desirable 177 ± 44.2 172.5 ± 42 -4.5 ± 23.7 0.66
Triglycerides (mg/dl) <200 desirable 191.7 ± 150.7 192.5 ± 108.2 0.8 ± 62.8 0.97
LDL cholesterol (mg/dl) <100 low risk 99.5 ± 34 96 ± 30.2 -3.5 ± 18.8 0.67
HDL cholesterol (mg/dl) >55 no risk 39.2 ± 11 41.3 ± 12.3 2.2 ± 9.8 0.61
Dipstick proteinuriaa Negative 1.7 ± 0.8 1.3 ± 0.5 -0.3 ± 1 0.46
  1. ul microliter, g/dl grams per deciliter, HCT hematocrit, MCV mean corpuscular volume, fl femtoliters, FBS fasting blood sugar, HbA1c hemoglobin A1c, mg/dl milligram per deciliter, mEq/l milliequivalents per liter, TSH thyroid-stimulating hormone, MIU/ml milli-international units per milliliter, PTH parathyroid hormone, pg/ml pictogram per milliliter, ESR erythrocyte sedimentation rate, mm/h millimeters per hour, CRP C-reactive protein, mg/l milligram per liter, ALT alanine aminotransferase, U/lit units per liter, AST aspartate aminotransferase, LDL low-density lipoprotein, HDL high-density lipoprotein
  2. Negative or 1 = 0 mg/dl; 2 = 15–30 mg/dl; 3 = 30–100 mg/dl; 4 = 100–300 mg/d; 5 = 300–1000 mg/dl; 6 > 1000 mg/dl