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Table 4 Changes in renal function parameters and blood pressure (BP) from 1 year before mesenchymal stromal cell (MSC) infusion, baseline and the 12-month follow up

From: Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients

Patient parameters Normal range -12 Baseline 12-month P value (RMA) Dif 1 (BV-1yp) P value Dif 1 Dif 2 (12 m-BV) P value Dif 2 Dif 3 (dif2- dif1) P valve Dif 3
SBP (mmHg) <120 123.8 ± 9.6 125.2 ± 10.3 126.8 ± 5.7 0.55 1.3 ± 6.8 0.65 1.6 ± 5.0 0.46 NA NA
DBP (mmHg) 60-80 77.7 ± 3.5 75.8 ± 5.6 78.8 ± 3.3 0.43 -1.8 ± 4.5 0.36 3 ± 6 0.27 NA NA
BUN (mg/dl) 7–20.6 28.5 ± 8.6 27.8 ± 10.5 29.5 ± 7.1 0.92 -0.6 ± 12.7 0.90 1.7 ± 4.3 0.38 NA NA
SCr (mg/dl) 0.4–1.4 2 ± 0.3 2.5 ± 0.4 2.5 ± 0.6 0.02b 0.5 ± 0.4 0.04b 0 ± 0.3 0.96 0.5 ± 0.5 0.05b
eGFRa 90–120 33.8 ± 5.3 26.7 ± 3.1 25.8 ± 6.2 0.01b -7.2 ± 6 0.03b -0.8 ± 3.9 0.62 -6.3 ± 7.5 0.09
Rt KL (cm) 10–12 NA 19.1 ± 2 19.5 ± 2 NA NA NA 0.4 ± 0.6 0.13 NA NA
Lt KL (cm) 10–12 NA 18.3 ± 2.4 18.7 ± 2.6 NA NA NA 0.4 ± 0.4 0.06 NA NA
  1. BV baseline visit, 1yp 1 year prior to intervention, 12 m 12 month after baseline, RMA repeated measures ANOVA, Dif difference, SPB systolic blood pressure, mmHg millimeter of mercury, NA not applicable, DBP diastolic blood pressure, BUN blood urea nitrogen, mg/dl milligram per deciliter SCr serum creatinine, eGFR estimated glomerular filtration rate, Rt right, KL kidney length, Lt left
  2. MDRD study formula (ml/min/1.73 m2)
  3. Significant