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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human adult mesangiogenic progenitor cells reveal an early angiogenic potential, which is lost after mesengenic differentiation

Fig. 3

Gene expression analysis. Endothelial-associated genes (a) were constitutively expressed by HUVECs (blue). PECAM and TIE1 were highly expressed in MPCs (green) and silenced during mesengenic differentiation. Conversely, P2-MSCs (red) activated TEK expression. MPC mesengenic differentiation was accompanied by mesenchymal/pericyte-associated gene (b) upregulation and significant reduction of MPC-related genes NES, OCT-4A, and SPP1 (c). Cytokine gene expression was not significantly modified following mesengenic induction (d). Differences over 1 log were evidenced for ANGPT2 and RANKL when comparing MPCs/P2-MSCs with HUVECs. **p < 0.01, ***p < 0.001. HUVEC human umbilical vein endothelial cell, MPC mesangiogenic progenitor cell, MSC mesenchymal stromal cell (Color figure online)

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