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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells

Fig. 8

Extracellular matrix expression of degenerate NPCs after NPCs were stimulated by BM-MSC exosomes. a qRT-PCR analysis showed an increase in ACAN (a), COL2A1 (b), SOX-9 (c) and TIMP-1 (f) and a decrease in MMP-1 (d) and MMP-3 (e) mRNA expression with the time of stimulation by BM-MSC exosomes. *P < 0.05, **P < 0.01, ***P < 0.001. b Western blot analysis showed that the effect of BM-MSC exosomes on NPCs in the protein profile was almost the same as gene expression

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Stem Cell Research & Therapy

ISSN: 1757-6512