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Table 1 Biochemical parameters of SDFTs treated with AT-MSCs suspended in autologous inactivated serum (AT-MSC-serum) and autologous inactivated serum alone (serum) and macroscopically normal tendon tissue (normal) from the same tendons 22 weeks after treatment

From: Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: a controlled experimental trial

  Group
Parameter AT-MSC-serum (n = 9) Serum (n = 9) Normal (n = 18)
DNA (μg/mg dwt) 3.91 ± 0.96a 4.24 ± 1.31a 1.99 ± 0.30b
GAG (μg/mg dwt) 21.38 ± 11.44a 26.80 ± 10.26a 6.47 ± 1.16b
Hyp (mg/mg dwt) 0.067 ± 0.001a 0.062 ± 0.012a 0.083 ± 0.009b
Total collagen (mg/mg dwt) 0.510 ± 0.076a 0.469 ± 0.093a 0.635 ± 0.071b
HP (mol/mol col) 0.196 ± 0.025ab 0.184 ± 0.026b 0.238 ± 0.040a
LP (mol/mol col) 0.016 ± 0.005a 0.017 ± 0.007a 0.013 ± 0.005a
HLys (mol/mol col) 6.90 ± 1.76a 7.39 ± 2.37a 7.38 ± 1.96a
  1. Values presented as mean ± standard deviation
  2. col collagen, dwt dry weight, GAG glycosaminoglycans, HLys Hydroxylysine, HP hydroxylysylpyridinoline, Hyp Hydroxyproline, LP lysylpyridinoline, AT-MSC adipose-derived mesenchymal stromal cell, SDFT superficial digital flexor tendon
  3. a,bDifferent superscript letters indicate significant differences (p < 0.05) between treatment groups