Skip to main content
Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

Fig. 1

Long-term pacing led to a dramatic decrease in the beating spike amplitude. a Plots are representative of the spontaneous beating characteristics of the paced VCMs; b quantification of the beating spike amplitude demonstrated a dramatic decrease in the 10-day and 14-day paced VCMs compared with the baseline controls; c however, the spontaneous beating rate revealed no significant difference during the whole pacing process; d VCMs were exposed to 0.5 ms duration and 1.2 Hz frequency pulses with 0, 1.5, 3, 4.5, 6 V voltage for 2 weeks. Cell viability was measured with CCK-8 assay and the results were presented as the means ± SD of three independent experiments. * p < 0.05, *** p < 0.001 according to paired a Student’s t test (Baseline/Control vs. each point)

Back to article page