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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

Fig. 4

Long-term pacing remodelled the cardiac action potential. a Plots of representative APs in VCMs; quantification of the resting membrane potential and action potential amplitude (mean ± SD, n = 8, b) were performed. The paced iPSC-CMs demonstrated significantly shorter APD50 and APD90 (mean ± SD, n = 8, c) than the age-matched controls. APA action potential amplitude, APD average action potential duration, RMP resting membrane potential. * p < 0.05, ** p < 0.005, *** p < 0.001 according to a one-way ANOVA test

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