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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

Fig. 5

Long-term pacing disturbed ion currents in cardiomyocytes. Patch-clamp studies revealed that the K+ currents (a) were significantly lower in the 100% Pace group than those in controls (mean ± SD, n = 6, d); both calcium current (I Ca ) (b) and L-type calcium current (I Ca, L ) (c) were significantly lower in paced VCMs than those in controls (mean ± SD, n = 6, d); qRT-PCR demonstrated that the expression of KCNQ1 and CACNA1C was significantly lower in the 40% Pace and 100% Pace groups (e). * p < 0.05, ** p < 0.005, *** p < 0.001 according to a one-way ANOVA test

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Stem Cell Research & Therapy

ISSN: 1757-6512