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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients

Fig. 5

Chondrogenic potential. Synovial MSCs from RA and OA patients were pelleted and cultured in chondrogenic medium for 21 days. a Representative macro pictures. b Histological sections stained with safranin O. c Histological sections immunostained with type II collagen. d Wet weight of the pellets. Average values with standard deviations are shown (n = 6). e Bern score for the evaluation of safranin O-stained cartilage pellet. f sGAG content per pellet. g Aggrecan and COL2A1 mRNA expression by real-time RT-PCR analyses. Gene expression fold changes are shown where the expression levels were normalized to OA as 1. Average values with standard deviations are shown (n = 6; RA: # 1, 2, 3, 4, 6, 7; OA: # 9, 10, 11, 12, 13, 14). OA osteoarthritis, RA rheumatoid arthritis, sGAG sulfated glycosaminoglycan

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