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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

Fig. 5

Effects of sorafenib treatment on intracellular signaling in EGF-stimulated MPM TICs. a Western blot analysis using antibodies specific to the phosphorylated proteins in MM1, MM3, and MM4 cells treated with IC50 sorafenib and stimulated with 20 ng/ml EGF for the indicated time periods (15–180 min). Representative immunoblots of three independent experiments are reported. b Images from independent experiments were quantified by band densitometric analysis and the resulting relative mean ratio of each protein/α-tubulin is shown. Values expressed as a percentage of the value obtained for the EGF-stimulated cells in the same blot. Results are mean ± SEM of three experiments. *p <0.05, **p <0.01. Dotted lines, basal (untreated) levels. EGF epidermal growth factor

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