Fig. 4From: The combination of nano-calcium sulfate/platelet rich plasma gel scaffold with BMP2 gene-modified mesenchymal stem cells promotes bone regeneration in rat critical-sized calvarial defectsHistological analysis of newly formed bone. a Hematoxylin and eosin staining of coronal sections through the midline of defects (between dashed line). Combination of nCS/PRP scaffold containing BMP2-modified MSCs promotes new bone formation. Scale bar = 2 mm. b Higher magnification of hematoxylin and eosin staining shown in A (black rectangle). Scale bar = 200 μm. c Quantitative analysis of newly formed bone (BV) to the total implant area (TV) (n = 3). ** p < 0.01; *** p < 0.001; ns: not statistically significant. B2 bone morphogenetic protein 2, MSCs mesenchymal stem cells, nCS nano-calcium sulfate, PRP platelet-rich plasmaBack to article page