Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation

Fig. 4

Involvement of HGF in the effect of ADHLSCs on HSC proliferation and procollagen type I secretion. a The numbers of floating and adhering HSCs after 24 h of incubation with ADHLSC- or HSC-conditioned medium was evaluated after pre-incubation with or without an anti-HGF antibody. There was significant, partial inhibition of the decrease in the number of adhering HSCs when incubated with ADHLSC-conditioned medium containing anti-HGF antibody (N > 5). b Inhibition of the effect of ADHLSC-conditioned medium on HSC pro-collagen type I secretion in the presence of an anti-HGF antibody (N = 3). c Anti-HGF antibody significantly inhibited the increase in HGF, IL-6, MMP1, and MMP2 secretion by HSCs. HGF hepatocyte growth factor, HSC hepatic stellate cells

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512