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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation

Fig. 5

Effect of ADHLSC transplantation on the expression of HSC activation markers in an established model of liver fibrosis. The mRNA levels of αSMA, Col1α1, Lox, and TIMP-1 in the livers of rats intrahepatically transplanted twice (n = 6) (a) or three times (n = 5) (b) with ADHLSCs without immunosuppression were estimated using RT-qPCR. c Total protein extracts were prepared from the three groups of rats as well as from naïve controls (n = 2), and immunoblotted with antibodies against markers of HSC activation and GAPDH as described in the “Materials and Methods” section. Downregulation of α-SMA, and fibronectin (Fn) is correlated to ADHLSC transplantation twice (n = 4) and three times (n = 4). ADHLSCs adult-derived human liver mesenchymal stem/progenitor cells

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Stem Cell Research & Therapy

ISSN: 1757-6512