Table 1 Therapeutic angiogenic effect of ASCs in animal IHD models
From: Therapeutic angiogenesis of adipose-derived stem cells for ischemic diseases
Animal model | Cell source | Delivery | Outcome | Underlying mechanisms |
|---|---|---|---|---|
Pig MI | Autologous ASCs | Intracoronary injection | LVEF↑, LV wall thickness↑, vascular density↑ | Differentiation into ECs and SMCs |
Rat MI | Rat ASCs | Intramyocardial injection | LVEF↑, LVFS↑, capillary vessels↑ | Differentiation into ECs |
Rat MI | Allogeneic SVF cells | Intramyocardial injection | LVEF↑, LVFS↑, ESD↓, ESV↓, capillary density↑ | Differentiation into ECs Paracrine secretion: VEGF, HGF, MCP-1, TIMP1, TIMP4 |
Rabbit MI | Rabbit ASCs | Intramyocardial injection | LVEF↑, peak + dP/dt↑, scar size↓, capillary density↑ | Differentiation into cardiomyocytes |
Mouse MI | Mouse ASCs | Intramyocardial injection | LVEF↑, LVEDV↑, LVESV↑, capillary density↑ | Differentiation into cardiomyocytes |
Rat MI | Rat ASCs | Intramyocardial injection | LVEF↑, LV wall thickness↑, capillary density↑, Percentage of viable myocardium↑, | Paracrine secretion: VEGF |
Nude rat MI | Human ASCs | Intramyocardial injection | LVEF↑, LVFS↑, EDV↓, ESV↓ LV wall thickness↑, infarct size↓, capillary density↑ | Paracrine secretion: VEGF, HGF, β-NGF |
Nude rat MI | Human ASCs | Intramyocardial injection | LVEF↑, LVFS↑, infarct size↓, capillary density↑ | Paracrine secretion: VEGF, bFGF, SDF-1α |
Pig I/R | Autologous ASCs | Intramyocardial injection | LVEF↑, ESD↓, ESV↓, EDV↓, capillary density↑ | Regulation of MMP/TIMP system |
Rat MI | 3D-cultured human ASCs | Intramyocardial injection | Infarct size↓, cardiomyocyte apoptosis↓, Capillary density↑ | Differentiated into ECs and VSMCs Paracrine secretion: VEGF |
Rat MI | Rat SVF cells | laid onto the epicardium | Relative infarcted volume↓, coronary vascular density↑, perfused vessels↑ | Paracrine secretion: VEGF |
Pig I/R | Allogeneic ASCs | Intracoronary injection | Vascular density↑ | Differentiation into VSMCs, ECs, and cardiomyocytes Paracrine secretion: VEGF |