Table 1 Changes in the gene expression levels of ADSCs and BRCAs/pBRCAs in co-culture compared to monoculture
Gene name | Fold-change (monoculture/co-culture) | Up-/downregulation |
|---|---|---|
Co-culture of ADSCs and EVSA-T | ||
Changes in the gene expression of ADSCs | ||
ETV4 | 2.3 (0.0) | ↓ |
Co-culture of ADSCs and MCF-7 | ||
Changes in the gene expression of ADSCs | ||
CCL-28 | 6.0 (0.3) | ↑ |
CCNA2 | 3.0 | ↓ |
CCNB1 | 3.0 | ↓ |
CDC2/CDK1 | 3.5 | ↓ |
CDH-1 | Undetermined → CT 36.1 | ↑ |
CX3CL-1 | 4.4 (1.1) | ↑ |
CXCL-12 | 5.8 (0.2) | ↑ |
E2F2 | 4.2 | ↓ |
GDF-5 | 2.6 (0.1) | ↓ |
GPR81/HCAR1 | 2.1 (0.1) | ↓ |
IL-6 | 2.3 (0.1) | ↑ |
KDR | 6.2 | ↓ |
MMP1 | 4.4 (0.1) | ↓ |
TLR2 | 2.6 (0.6) | ↓ |
TNFSF-10 | 3.0 (0.2) | ↑ |
PPP1R1B | 8.7 | ↑ |
PTGS2 | 3.6 (0.2) | ↑ |
TUBA4A | 3.0 | ↓ |
WISP-1 | 21 (1.8) | ↑ |
Changes in the gene expression of MCF-7 | ||
IL18 | 2.1 (0.1) | ↓ |
KDR | 3.0 | ↑ |
TNFSF-10 | 4.6 (0.5) | ↑ |
Co-culture of ADSCs and MDA-MB-231 | ||
Changes in the gene expression of ADSCs | ||
CCL-8 | 2.4 (0.1) | ↑ |
CSF-3 | 8.3 (0.8) | ↑ |
CXCL-1 | 10 (0.4) | ↑ |
CXCL-2 | 2.3 (0.3) | ↑ |
CXCL-3 | 3.2 (0.1) | ↑ |
CXCL-6 | 9.7 (0.3) | ↑ |
IL-6 | 3.0 (0.2) | ↑ |
IL-8 | 4.6 (0.4) | ↑ |
MMP1 | 2.6 (0.3) | ↓ |
Changes in the gene expression of MDA-MB-231 | ||
CXCL-2 | 3.7 (0.1) | ↑ |
CXCL-3 | 4.2 (0.1) | ↑ |
IL-6 | 2.3 (0.1) | ↑ |
IL-8 | 4.7 (0.1) | ↑ |
MMP-3 | 4.8 (0.2) | ↑ |
MMP-10 | 7.2 (0.8) | ↑ |
PSCA | 3.5 (0.7) | ↑ |
TLR-2 | 2.0 (0.3) | ↑ |
Co-culture of ADSCs and SK-BR-3 | ||
Changes in the gene expression of ADSCs | ||
CCL-20 | 2.4 (0.5) | ↓ |
CXCL-1 | 3.5 (0.0) | ↓ |
CSF-3 | 5.7 (0.4) | ↓ |
CXCL-3 | 5.0 (0.1) | ↓ |
CXCL-12 | 2.4 (0.0) | ↑ |
IL-8 | 5.5 (0.2) | ↓ |
PTGS2 | 3.2 (0.1) | ↓ |
SERPINB5 | 2.4 (1.1) | ↓ |
TLR2 | 2.6 (0.4) | ↓ |
TNFSF-10 | 3.3 (0.1) | ↑ |
Changes in the gene expression of SK-BR-3 | ||
CCL-20 | 2.5 (0.0) | ↑ |
CCL-26 | 3.0 (0.3) | ↑ |
CEACAM-1 | 3.0 (0.3) | ↑ |
CSF-3 | 2.4 (0.5) | ↓ |
CXCL-1 | 2.6 (0.1) | ↑ |
EPHB2 | 2.3 (0.2) | ↑ |
MCAM | 2.1 (0.1) | ↑ |
MMP2 | 4.4 (0.1) | ↑ |
SERPINB5 | 2.9 (0.7) | ↓ |
RECK | 2.0 (0.2) | ↓ |
STAT4 | 7.7 (1.2) | ↑ |
TLR-2 | 2.0 (0.3) | ↑ |
TNFSF-10 | 2.2 (0.2) | ↑ |
TMPRSS-4 | 2.7 (0.4) | ↑ |
Co-culture of ADSCs and ZR75-30 | ||
Changes in the gene expression of ADSCs | ||
CX3CL-1 | 4.6 (0.7) | ↑ |
CXCL-10 | 3.0 (0.6) | ↑ |
CXCL-14 | 2.0 (0.3) | ↑ |
CXCR4 | 3.2 (0.2) | ↓ |
MET | 2.0 (0.1) | ↓ |
PSCA | 2.3 (0.1) | ↓ |
Changes in the gene expression of ZR75-30 | ||
CCL2 | 2.3 (0.1) | ↑ |
FXYD5 | 3.0 (0.1) | ↑ |
PSCA | 7.9 (0.2) | ↓ |
CXCL-14 | 7.4 (1.5) | ↓ |
MET | 4.4 (1.1) | ↓ |
MMP-2 | 5.4 (1.9) | ↓ |
STAT4 | 5.1 (0.7) | ↑ |
Co-culture of ADSCs and primary BRCAs | ||
Changes in the gene expression of ADSCs | ||
CCL-7 | 7.5 (0.2) | ↑ |
CD44 | 2.0 (0.0) | ↓ |
CD82 | 10 (0.4) | ↑ |
EPHB2 | 2.1 (0.1) | ↑ |
FGF-2 | 3.9 (0.1) | ↑ |
GNRH1 | 2.1 (0.2) | ↓ |
KISS1R | 8.6 (2.5) | ↓ |
MMP-1 | 17 (0.8) | ↑ |
MMP-3 | 13 (1.3) | ↑ |
PSCA | 4.3 (0.3) | ↓ |
S100A4 | 2.0 (0.1) | ↓ |
SERPINE1 | 8.0 (0.1) | ↑ |
TNFSF-10 | 3.5 (0.2) | ↓ |
WISP1 | 33 (0.7) | ↑ |
Changes in the gene expression of primary BRCAs | ||
CD82 | 2.1 (0.2) | ↑ |
DARC | 2.8 (0.1) | ↓ |
GNRH1 | 2.3 (0.1) | ↑ |
MMP-1 | 2.3 (0.1) | ↑ |
MMP-3 | 3.4 (0.3) | ↑ |
MMP-7 | 5.1 (0.5) | ↑ |
TIMP-4 | 7.6 (1.8) | ↑ |
TNFSF-10 | 3.0 (0.3) | ↓ |
TMPRSS4 | Undetermined → CT 32.4 | ↑ |
TWIST1 | 2.0 (0.0) | ↑ |
WISP1 | 29 (0.9) | ↑ |