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Table 2 Changes in the protein expression levels of ADSCs and BRCAs/pBRCAs in co-culture compared to monoculture

From: The impact of human adipose tissue-derived stem cells on breast cancer cells: implications for cell-assisted lipotransfers in breast reconstruction

Protein

ADSC monoculture (pg/ml)

Respective BRCA monoculture (pg/ml)

Co-culture (pg/ml)

Fold-change for ADSC (monoculture/co-culture)

Fold-change for respective BRCA (monoculture/co-culture)

Co-culture of ADSCs and EVSA-T cell line

 CCL2

1755 (65)

ND

1421 (108)

0.9 →

NA ↑↑

 EMMPRIN

594 (46)

208 (7.6)

828 (37)

1.4 →

4.0 ↑

 HGF

1803 (159)

ND

1104 (155)

0.6 →

NA ↑↑

 IL-6

62 (11)

ND

53 (7.1)

0.9 →

NA ↑↑

 IL-7

8.4 (6.3)

ND

14 (6.8)

1.7 →

NA ↑

 IL-8

4261 (673)

ND

3818 (665)

0.9 →

NA ↑↑

 MMP-1

165,407 (32,918)

n.d

80,345 (3137)

0.5 →

NA ↑↑

 MMP-2

61,271 (3320)

ND

66,795 (5514)

1.1 →

NA ↑↑

 MMP-3

8274 (355)

23 (1.5)

5356 (142)

0.7 →

233 ↑↑

 MMP-7

208 (40)

ND

156 (29)

0.8 →

NA ↑

 MMP-9

82 (5.4)

32 (2.8)

70 (2.9)

0.9 →

2.2 ↑

 MMP-10

385 (23)

21 (2.7)

258 (6.8)

0.7 →

12 ↑

 VEGF

47 (0.0)

ND

38 (4.6)

0.8 →

NA ↑↑

Co-culture of ADSCs and MCF-7 cell line

 CCL2

2004 (99)

ND

1007 (75)

0.5 →

NA ↑↑

 CCL3

16 (0.7)

14 (1.6)

17 (2.0)

1.1 →

1.2 →

 CCL5

5.1 (3.4)

12 (7.6)

4.9 (2.6)

1.0 →

0.4 ↓

 CXCL10

2.3 (0.1)

1.9 (0.1)

2.1 (0.2)

0.9 →

1.1 →

 EMMRPIN

768 (34)

551 (28)

1073 (57)

1.4 →

2.0 →

 Eotaxin

1.0 (0.1)

1.2 (0.2)

0.9 (0.1)

0.8 →

0.8 →

 G-CSF

91 (9.7)

29 (5.2)

55 (8.3)

0.6 →

1.9 →

 GM-CSF

1.7 (0.1)

1.0 (0.1)

1.3 (0.1)

0.7 →

1.3 →

 HGF

2095 (244)

ND

1488 (67)

0.7 →

NA ↑↑

 IL-4

18 (1.0)

12 (0.6)

16 (1.3)

0.9 →

1.3 →

 IL-5

2.8 (0.1)

2.8 (0.2)

2.9 (0.3)

1.0 →

1.0 →

 IL-6

160 (20)

ND

160 (23)

1.0 →

NA ↑↑

 IL-8

5330 (633)

ND

2982 (367)

0.6 →

NA ↑↑

 IL-10

4.6 (0.5)

4.0 (0.4)

4.9 (0.4)

1.1 →

1.2 →

 IL-12

11.7 (4.2)

ND

10.6 (5.1)

0.9 →

NA ↑

 IL-13

10 (1.0)

15 (0.5)

20 (1.7)

2.0 ↑

1.3 →

 IL-1Ra

24 (1.7)

24 (1.1)

25 (1.5)

1.0 →

1.0 →

 INF-α

80 (6.5)

ND

46 (7.3)

0.6 →

NA ↑↑

 MMP-1

85,387 (18,267)

30 (5.4)

17,881 (1437)

0.2 →

596 ↑↑

 MMP-2

51,127 (3291)

ND

74,585 (6060)

1.5 →

NA ↑↑

 MMP-3

3514 (281)

40 (0.0)

3,905 (173)

1.1 →

98 ↑↑

 MMP-9

112 (7,6)

112 (3.2)

99 (4.0)

0.9 →

0.9 →

 MMP-10

193 (76)

41 (3.9)

236 (6.7)

1.2 →

5.8 ↑

 VEGF

44 (4.7)

ND

48 (6.1)

1.1 →

NA ↑↑

Co-culture of ADSCs and MDA-MB-231 cell line

 CCL2

965 (140)

2.4 (0.0)

949 (162)

1.0 →

395 ↑↑

 EMMPRIN

496 (20)

434 (30)

882 (53)

1.8 →

2.0 →

 HGF

889 (206)

9.2 (4.9)

708 (129)

0.8 →

77 ↑↑

 IL-4

1.7 (1.0)

1.4 (0.0)

0.9 (0.6)

0.5 →

0.6 →

 IL-6

199 (32)

80 (3.9)

207 (36)

1.0 →

2.6 ↑

 IL-7

22 (2.6)

17 (2.0)

15 (6.4)

0.7 →

0.9 →

 IL-8

3238 (528)

350 (32)

2836 (474)

0.9 →

8.1 ↑

 MMP-1

58,500 (5616)

5637 (414)

32,448 (3927)

0.6 →

5.8 ↑

 MMP-2

17,767 (1796)

ND

18,290 (1907)

1.0 →

NA ↑↑

 MMP-3

2185 (79)

196 (11)

1994 (118)

0.9 →

10 ↑

 MMP-9

105 (4.0)

93 (6.1)

101 (5.8)

1.0 →

1.1 →

 MMP-10

160 (7.0)

50 (3.1)

151 (11)

0.9 →

3.0 ↑

 VEGF

22 (12)

24 (0.0)

25 (9.2)

1.1 →

1.0 →

Co-culture of ADSCs and SK-BR-3 cell line

 bFGF

4.8 (0.0)

ND

ND

  

 CCL2

1200 (134)

24 (5.8)

699 (92)

0.6 →

29 ↑↑

 EMMPRIN

566 (22)

456 (13)

1030 (50)

1.8 →

2.3 →

 HGF

975 (159)

ND

537 (94)

0.6 →

NA ↑↑

 IL-4

1.2 (0.9)

ND

0.6 (0.6)

0.5 →

NA ↑↑

 IL-6

175 (20)

4.3 (1.6)

145 (15)

0.8 →

34 ↑↑

 IL-7

13 (8.1)

ND

6.9 (5.6)

0.5 ↓

NA ↑↑

 IL-8

3581 (263)

66 (15)

2540 (337)

0.7 →

39 ↑↑

 IL-1Ra

20 (0.0)

ND

ND

NA ↓

NA →

 INF-α

30 (7.5)

ND

ND

NA ↓

NA →

 MMP-1

62,844 (4604)

29 (2.0)

37,601 (2334)

0.6 →

1297 ↑

 MMP-2

42,296 (2367)

ND

59,467 (4706)

1.4 →

NA ↑↑

 MMP-3

3472 (316)

48 (3.0)

3261 (251)

0.9 →

68 ↑↑

 MMP-9

111 (8.5)

255 (14)

128 (10)

1.2 →

0.5 →

 MMP-10

231 (15)

33 (13)

219 (10)

1.0 →

6.4 ↑

 VEGF

24 (9.7)

ND

23 (7.9)

1.0 →

NA ↑↑

Co-culture of ADSCs and ZR75-30 cell line

 CCL2

3603 (375)

112 (11)

3137 (212)

0.9 →

28 ↑↑

 CCL3

21 (2.1)

16 (1.4)

18 (2.0)

0.9 →

1.2 →

 CCL4

2.2 (0.7)

ND

2.7 (0.0)

1.2 →

NA ↑

 CCL5

7.8 (4.1)

6.4 (2.2)

3.1 (1.2)

0.4 ↓

0.5 →

 CXCL10

2.9 (0.3)

2.1 (0.1)

2.3 (0.3)

0.8 →

1.1 →

 EMMPRIN

819 (40)

21 (2.5)

594 (4.9)

0.7 →

28 ↑↑

 Eotaxin

1.2 (0.3)

1.3 (0.2)

0.9 (0.1)

0.8 →

0.7 →

 G-CSF

85 (15)

32 (8.5)

54 (14)

0.6 →

1.7 →

 GM-CSF

2.2 (0.4)

1.1 (0.0)

1.7 (0.2)

0.8 →

1.5 →

 HGF

4672 (557)

ND

2589 (239)

0.6 →

NA ↑↑

 IL-4

21 (3.0)

13 (0.0)

18 (1.6)

0.9 →

1.4 →

 IL-5

3.0 (0.2)

2.8 (0.1)

3.0 (0.3)

1.0 →

1.1 →

 IL-6

186 (42)

ND

151 (10)

0.8 →

NA ↑↑

 IL-7

24 (11)

ND

ND

NA ↓↓

NA ↓↓

 IL-8

4686 (714)

33 (7.8)

2578 (316)

0.6 →

78 ↑↑

 IL-10

5.2 (0.3)

4.2 (0.3)

5.0 (0.8)

1.0 →

1.2 →

 IL-12

20 (5.8)

ND

13 (8.5)

0.7 →

NA ↑↑

 IL-13

23 (2.8)

16 (0.9)

20 (1.7)

0.9 →

1.3 →

 IL-1Ra

28 (3.6)

26 (1.4)

26 (3.2)

0.9 →

1.0 →

 INF-α

116 (9.7)

ND

90 (6.3)

  

 INF-γ

1.2 (0.8)

0.2 (0.2)

2.1 (0.0)

1.8 →

11 ↑

 MMP-1

116,547 (31,612)

18 (0.6)

43,964 (2942)

0.4 ↓

2442 ↑↑

 MMP-2

121,997 (6892)

ND

131,537 (2758)

1.1 →

NA ↑↑

 MMP-3

5264 (444)

43 (2.0)

2665 (210)

0.5 →

62 ↑↑

 MMP-9

110 (4.2)

89 (5.3)

106 (6.5)

1.0 →

1.2 →

 MMP-10

292 (17)

39 (2.6)

173 (6.6)

0.6 →

4.4 ↑

 VEGFA

56 (8.4)

ND

49 (5.0)

  

Co-culture of ADSCs and primary BRCAs

 bFGF

8.7 (0.0)

60 (9.2)

46 (7.7)

5.3 ↑

0.8 →

 CCL2

5241

24,396 (2324)

35,559 (1471)

16 ↑↑

1.4 →

 CCL3

ND

135

126

NA ↑↑

1.0 →

 CCL4

ND

37

48

NA ↑↑

1.3 →

 CCL5

37 (11)

136 (9.2)

110 (14)

3.0 ↑

0.8 →

 CXCL-9

ND

271 (9.2)

553 (68)

20 ↑

2.0 →

 CXCL-10

6.5 (0.4)

572 (9.2)

89 (15)

13.6 ↑

6.4 ↓

 EGF

ND

71 (9.2)

49 (22)

NA ↑↑

0.7 →

 EMMRPIN

104 (12)

1908 (281)

1949 (122)

19 ↑↑

1.0 →

 Eotaxin

1.1 (0.6)

4.2 (9.2)

6.5 (1.4)

5.8 ↑

1.6 →

 G-CSF

ND

1604 (9.2)

1396 (142)

NA ↑

0.8 →

 GM-CSF

6.8 (0.3)

23 (9.2)

37 (0.7)

5.4 ↑

1.5 →

 HGF

1740 (99)

398 (9.2)

1254 (99)

0.7 →

3.2 ↑

 IL-1b

ND

84 (9.2)

75 (22)

NA →

0.9 →

 IL-2

ND

10 (9.2)

7.3 (2.6)

NA →

0.7 →

 IL-4

40 (4.2)

105 (9.2)

121 (6.3)

3.0 ↑

1.2 →

 IL-5

ND

5.1 (9.2)

6.9 (1.7)

NA ↑

1.3 →

 IL-6

1222 (114)

7768 (1007)

12,121 (409)

20 ↑↑

1.5 →

 IL-7

45 (37)

248 (9.2)

251 (32)

5.6 ↑

1.0 →

 IL-8

3224 (150)

17,925 (2899)

34,099 (1586)

11 ↑↑

1.9 →

 IL-10

22 (1.7)

62 (9.2)

56 (4.6)

2.6 ↑

0.9 →

 IL-12

47 (5.2)

179 (9.2)

207 (11)

4.4 ↑

1.2 →

 IL-13

23 (4.1)

57 (9.2)

63 (11)

2.7 ↑

1.1 →

 IL-15

48 (22)

363 (9.2)

235 (49)

4.9 ↑

0.7 →

 IL-17

ND

22

27

NA ↑

1.2 →

 IL-2R

90 (65)

398 (9.2)

425 (113)

4.7 ↑

1.0 →

 INF-α

172 (16)

950 (9.2)

1186 (35)

6.9 ↑

1.3 →

 INF-y

4.7 (0.0)

24 (9.2)

20 (6.4)

4.4 ↑

0.8 →

 MMP-1

8045 (483)

3606 (509)

12,850 (1750)

1.6 →

3.6 ↑

 MMP-2

75,480 (3780)

17,192 (2131)

108,563 (4932)

1.4 →

6.3 ↑

 MMP-3

1218 (51)

757 (145)

5005 (395)

4.1 ↑

6.6 ↑

 MMP-9

94 (7.4)

873 (107)

852 (50)

9.0 ↑

1.0 →

 MMP-10

82 (2.5)

542 (70)

857 (54)

11 ↑↑

1.6 →

 TNF-α

2.0 (2.6)

18 (9.2)

20 (4.2)

9.8 ↑

1.1 →

 VEGF

131 (16)

518 (9.2)

629 (32)

4.8 ↑

1.2 →

  1. Standard deviation is given in brackets
  2. Results from 0 to 9.9 are shown with one decimal point, results for 10 or higher are displayed without decimal points
  3. ND not detectable, NA not applicable