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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells

Fig. 4

Effect of soluble ECMs on MSC pellet biochemical composition and gene expression. a MSC pellets were cultured in one of four medium conditions for 21 days. b Biochemical composition of pellets reveals anabolic and mitogenic effects for all supplements; cECM promoted the greatest relative sGAG production (p < 0.05, n = 9). c Gene expression analysis on day 21 shows chondrogenic effects of TGF-β, tenogenic effects of tECM, and chondrogenic and osteogenic effects of cECM (p < 0.05, n = 9). Statistically significant differences are indicated by overlying horizontal lines. cECM urea-extracted cartilage extracellular matrix, sGAG sulfated glycosaminoglycan, tECM urea-extracted tendon extracellular matrix

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