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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells

Fig. 7

Independent and synergistic effects of cECM and TGF-β on chondrogenesis of MSCs seeded in 3D photocrosslinked GelMA hydrogels. a MSC-seeded GelMA hydrogel constructs, with or without cECM enhancement, were cultured in chondrogenic medium, with or without TGF-β supplementation, for up to 21 days. b Gene expression analysis shows independent and synergistic effects of cECM and TGF-β (p < 0.05, n = 9). c Biochemical composition analysis shows synergistic effect of cECM and TGF-β in enhancing absolute and normalized sGAG production (p < 0.05, n = 9). Statistically significant differences are indicated by overlying horizontal lines. cECM urea-extracted cartilage extracellular matrix, sGAG sulfated glycosaminoglycan, TGF transforming growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512