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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Exosome miR-371b-5p promotes proliferation of lung alveolar progenitor type II cells by using PTEN to orchestrate the PI3K/Akt signaling

Fig. 1

A549-derived Exo-miRs promote ATIIC-specific proliferation. Bar graph representation of the content of SPC-expressing cells in the differentiated cultures of hESCs to show the effects of each ATIIC phenotype-derived CM (a), exosomes (c) or Exo-miRs (d) on ATIIC-specific differentiation (day 12) and proliferation (day 16). b Western blotting of TSG101, CD63 and HSP70 in exosomes derived from cultured A549 (1), hiPSC-ATIICs (2) and hATIICs (3). e Representative immunofluorescent staining of the SPC-expressing cells (red) in the differentiated cultures of hESCs after treatment with A549-, hiPSC-ATIIC-, or hATIIC-derived exosomes or Exo-miRs on days 12 and 16. ATIICs alveolar epithelial type II cells, CM conditioned medium, DAPI 4′,6-diamidino-2-phenylindole, DM differentiation medium, Exo-miRs exosome miRNAs, hATIICs human primary ATIICs, hiPSC-ATIICs human induced pluripotent stem cell-derived ATIICs

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