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Table 1 Important components of SVF, respective sizes, and surface markers

From: Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation

Cell types of the SVF

Cell size range [in µm]*

Molecular markers# [1, 26, 29]

Positive

Negative

ADSC

~10–25 μm and reported up to 200+ μm in culture [34,35,36]

CD34, CD73, CD13, CD90, CD105, CD29

CD31, CD45, CD144

EPC

~7–8 μm (smallest defined) [37]

CD34, CD31, CD133, CD146

CD45

EC

~10–30 μm [38]

CD31, FVIII

CD34

T regulatory cells

~7–12 μm [39, 40]

CD4, CD25, Foxp3, CD8

Macrophages

~20 μm [41]

CD45, CD14, CD34, CD206

Smooth muscle cells

~3–20 μm in width and 20–500 μm in length [42, 43]

Smooth muscle actin (SMA)

Pericytes

Up to ~70 μm in length [44]

CD146, CD90, CD73, CD44, CD29, CD13

CD34, CD45, CD56

Pre-adipocytes

~10 μm [45]

CD34

CD45, CD31, CD146

  1. *Diameter; unless mentioned otherwise
  2. The Table captures the approximate range of cell sizes as reported in different studies [34,35,36,37,38,39,40,41,42,43,44,45] and provides an overview of surface antigens for the respective cell type [1, 26, 29]. # Includes surface or CD markers, cytoplasmic and nuclear factors
  3. ADSC adipose-derived stem/stromal cells, EC endothelial cells, EPC endothelial precursor cells, SVF stromal vascular fraction