Table 2 Overview of characteristics of native and culture expanded ADSCs
Factors | Native ADSCs [52] | |
|---|---|---|
Cell surface markers | CD34, CD73, CD90, CD13 | CD73, CD90, CD13; (CD34 expression decreases and ceases with in vitro expansion) |
Morphology | Branched, with up to 80-μm long protrusions forming a network surrounding mature adipocytes | Typical elongated, stromal cell shape, ~10–25 μm and reported to go up to 200 + μm |
Location | Both perivascular and stromal positions in situ | Not applicable |
Functional characteristics | • Support adipose tissue growth. • Might differentiate to form mature adipocytes | • Facilitate and/or participate in angiogenesis. • Potential for differentiation to adipo-, osteo-, and chondrogenic lineages. • Immunomodulatory properties. |