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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Global gene expression profiling and senescence biomarker analysis of hESC exposed to H2O2 induced non-cytotoxic oxidative stress

Fig. 3

Crosstalks between the pivot genes CNBP and NEDD1 and their functional gene modules. a CBNP crosstalks with a functional gene module “translational termination, SRP-dependent co-translational protein targeting to membrane, translational elongation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, translational initiation and viral transcription” through the anti-correlated co-expressed interaction with the genes RPL23A, RPS16 and RPS19. The red edges represent the anti-correlated co-expressed gene-gene interactions, and the grey edges represent the correlated co-expressed gene-gene interactions. b NEDD1 pivot gene crosstalks with two functional gene modules: one is involved in the biological processes of toxin transport, binding of sperm to zona pellucida and ‘de novo’ posttranslational protein folding mainly through the anti-correlated co-expressed interactions with genes CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7 and TCP1 (on the left), while the other is related with cilium assembly, G2/M transition of mitotic cell cycle, centriole replication, spindle assembly, microtubule bundle formation and determination of left/right symmetry mainly through the correlated co-expressed interactions with genes CEP152, CEP192, CP110, KIAA1009, KIAA0562, ODF77, ODF1, NME7, CCDC77, PLK4 and C14orf145 (on the right)

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