Fig. 3

EPCs transplantation reduced the leakage of IgG after tMCAO in diabetic mice. A Photomicrographs shows the leaked IgG protein in brown color from brain vessel at 12 h and 24 h after tMCAO. Higher magnification of the boxed area in a to e were shown in f to j, respectively. Scale bar = 200 μm. B Bar graph shows the quantification of IgG protein in the sham, PBS-treated and EPC-treated mice. Data are mean ± SD, n = 6–8 per group. ^* p < 0.05, EPC-treated vs. PBS-treated mice. EPC endothelial progenitor cell, IgG immunoglobulin, PBS phosphate-buffered saline