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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α

Fig. 5

HIF-1α mRNA expression at 24 h after tMCAO in diabetic mice. A Bar graph shows the quantification of HIF-1α mRNA level in the sham, PBS-treated and EPC-treated brain tissue at 24 h after tMCAO. Data were normalized to the internal control. Data are as mean ± SD, n = 4 per group. * p < 0.05, EPC-treated vs. PBS-treated mice. B Photomicrograph showed that CD31 (red color) and HIF-1α (green color) double immunostaining. Yellow color indicated that CD31 and HIF-1α well merged, indicating ECs could express HIF-1α. Scale bar = 25 μm. EPC endothelial progenitor cell, HIF-1α hypoxia-inducible factor-1α, PBS phosphate-buffered saline

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