Fig. 4
From: Influences of age-related changes in mesenchymal stem cells on macrophages during in-vitro culture
Gene expression levels of the M2-related enzyme/cytokines Arg1 (a), IL-10 (b) and TGFβ (c) as well as of the M1-related enzyme/cytokines TNFα (d), iNOS (e) and IL-1β (f), analyzed by qRT-PCR in RAW264.7 cells following coculture with YMSCs and AMSCs (with or without IFNγ stimulation); RAW264.7 cells without coculture served as control. Values are relative to GAPDH and normalized to the control group. Data shown as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001, significant differences when compared to control; △ p < 0.05, △△△ p < 0.001, a significant difference between the indicated groups; NS p > 0.05, no significant difference between the indicated groups. AMSC aged bone marrow-derived mesenchymal stem cell, YMSC young bone marrow-derived mesenchymal stem cell, Arg1 Arginase-1, IL interleukin, TGFβ transforming growth factor beta, TNFα tumor necrosis factor alpha, iNOS inducible nitric oxide synthase