Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

Table 2 Impact of obstetric factors on proliferation and chondrogenic differentiation

Obstetric factors	P1 doubling time (h)	P2 doubling time (h)	Volume (mm³)	Proteoglycans (%)	Collagens (%)	Sox-9/ RP29	Aggrecans/RP29	Coll2T/RP29
Birth weight (g)		+
Amenorrhea weeks at birth		+
Full-term birth		+
Maternal smoking		+				–
Normal pregnancy: neonatal criteria		+
Preeclampsia		–
Managed labor	+			+
Oxytocin infusion	+
Placental weight		+			–
Twins				–
Normal pregnancy (labor and delivery criteria)			+
Arterial hypertension				+
Labor duration			–
Long labor			–			+
Normal pregnancy (maternal criteria)								+
Cryopreservation duration (days)				+	–
R ² =	0.12	0.14	0.13	0.25	0.25	0.23	0	0.16

+ positive impact (i.e., decreased doubling time or increased marker of chondrogenic differentiation), – negative impact (i.e., increased doubling time of decreased marker of chondrogenic differentiation). Coll2T total collagen type 2, P passage

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