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Table 2 Impact of obstetric factors on proliferation and chondrogenic differentiation

From: Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

Obstetric factors P1 doubling time (h) P2 doubling time (h) Volume (mm3) Proteoglycans (%) Collagens (%) Sox-9/ RP29 Aggrecans/RP29 Coll2T/RP29
Birth weight (g)   +       
Amenorrhea weeks at birth   +       
Full-term birth   +       
Maternal smoking   +      
Normal pregnancy: neonatal criteria   +       
Preeclampsia        
Managed labor +    +     
Oxytocin infusion +        
Placental weight   +      
Twins        
Normal pregnancy (labor and delivery criteria)    +      
Arterial hypertension     +     
Labor duration        
Long labor      +   
Normal pregnancy (maternal criteria)         +
Cryopreservation duration (days)     +    
R 2 = 0.12 0.14 0.13 0.25 0.25 0.23 0 0.16
  1. + positive impact (i.e., decreased doubling time or increased marker of chondrogenic differentiation), – negative impact (i.e., increased doubling time of decreased marker of chondrogenic differentiation). Coll2T total collagen type 2, P passage