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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo

Fig. 6

PICs show multi-potent potential in vitro and in vivo. a–h Representative confocal micrographs of C9 PICs following directed differentiation into endothelial (a), hepatic (b,c) and neuronal (e–h) lineages. d Flow cytometric analysis of C9 PICs for albumin expression after 14 days of hepatic differentiation. i Immunohistochemical staining of teratomas from PIC/ESC-treated mice showing GFP+ cells expressing markers of the three germ layers. Arrows indicate co-staining of green fluorescent protein (GFP) with αFP (endoderm), β3-tubulin (ectoderm), desmin, and smooth muscle actin (SMA) (mesoderm). Scale bars = 50 μm in all micrographs. ChAT choline acetyltransferase, CK cytokeratin, ENO2 gamma-enolase, GFAP glial fibrillary acidic protein, vWF von Willebrand factor

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Stem Cell Research & Therapy

ISSN: 1757-6512