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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics

Fig. 4

hAMSCs improved the proliferation rate of hGCs and upregulated the expression of hGC markers more forcefully than hAECs. a Schematic diagram of different degrees of ovarian aging mice model and patients. b Schematic overview of hGC filtered procedures. c Expression levels of ki67+FSHR+ hGCs tested after coculture with hAECs and hAMSCs respectively. d Number of ki67+AMH+ hGCs evaluated after coculture with hAECs and hAMSCs respectively. e Expression level of ki67+FOXL2+ hGCs tested after coculture with hAECs and hAMSCs respectively. f Number of ki67+CYP19A1+ hGCs evaluated after coculture with hAECs and hAMSCs respectively. Experiments were carried out after 7 days of coculture, n = 3. Error bars indicate SD. *p < 0.05, ***p < 0.001, compared with control group; #p < 0.05, ##p < 0.01, compared with hAEC group. DOR decreased ovarian reserve, POF premature ovarian failure, Sal saline, hGC human ovarian granulosa cell, hAEC human amniotic epithelial cell, hAMSC human amniotic mesenchymal stem cell

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