Fig. 4From: Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristicshAMSCs improved the proliferation rate of hGCs and upregulated the expression of hGC markers more forcefully than hAECs. a Schematic diagram of different degrees of ovarian aging mice model and patients. b Schematic overview of hGC filtered procedures. c Expression levels of ki67+FSHR+ hGCs tested after coculture with hAECs and hAMSCs respectively. d Number of ki67+AMH+ hGCs evaluated after coculture with hAECs and hAMSCs respectively. e Expression level of ki67+FOXL2+ hGCs tested after coculture with hAECs and hAMSCs respectively. f Number of ki67+CYP19A1+ hGCs evaluated after coculture with hAECs and hAMSCs respectively. Experiments were carried out after 7 days of coculture, n = 3. Error bars indicate SD. *p < 0.05, ***p < 0.001, compared with control group; #p < 0.05, ##p < 0.01, compared with hAEC group. DOR decreased ovarian reserve, POF premature ovarian failure, Sal saline, hGC human ovarian granulosa cell, hAEC human amniotic epithelial cell, hAMSC human amniotic mesenchymal stem cellBack to article page