Fig. 5
Effects of c-Met-BMSC transplantation on the survival rates and liver function in ALF rats. A total of 54 rats were randomly divided into three groups: c-Met-BMSC, control BMSC, and NS groups (n = 12 in each group). The rats were injected with d-GalN/LPS to induce ALF. After 24 h, the c-Met-BMSC and control BMSC groups were given a transfusion of 1.0 × 107/kg cells suspended in 1 mL of normal saline (NS) respectively, while the NS group was given 1 mL of NS. The blood samples were collected at 0, 24, 48 and 72 h post-d-GaIN/LPS injection. a The survival rates in the c-Met-BMSC, control BMSC, and NS groups; levels of serum b alanine transferase (ALT), c aspartate aminotransferase (AST), and d total bilirubin (TBil) in treatment of ALF rats. Data were expressed as mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001. BMSC bone marrow-derived mesenchymal stem cell, d -GalN d-galactosamine, LPS lipopolysaccharide