Fig. 1

Growth factor and cytokine secretion by DPPSC. a Representative images of cytokine antibody arrays showing the presence of several growth factors in DPPSC-conditioned medium (right panel) compared to uncultured media (left panel). b Analysis of the increase in spot intensity (in arbitrary units; AU) in DPPSC-cultured vs uncultured media. Only increments higher than 1000 AU are shown in the figure (n = 4, results are displayed as mean ± s.e.m.). c Concentration (μg/ml) of proteins in b in the DPPSC-cultured medium (n = 4, results are displayed as mean ± s.e.m.). Abbreviations: ENA-78 C-X-C motif chemokine 5 (CXCL5), GRO growth-regulated oncogene, GRO-α growth-regulated oncogene alpha, IL-8 interleukin 8, MCP-1 monocyte chemoattractant protein 1, RANTES regulated on activation normal T cell expressed and secreted (CCL5), SDF-1 stromal cell-derived factor 1, TARC thymus and activation regulated chemokine, TGF-β1 transforming growth factor beta 1, TNF-β tumor necrosis factor beta, EGF epidermal growth factor, IGF-I insulin-like growth factor 1, ANG angiogenin, VEGF vascular endothelial growth factor, PDGF-BB platelet-derived growth factor-BB, BDNF brain-derived neurotrophic factor, GDNF glial cell-derived neurotrophic factor, HGF hepatocyte growth factor, IGFBP-2 insulin-like growth factor-binding protein 2, IP-10 interferon gamma-induced protein 10, LIF leukemia inhibitory factor, LIGHT TNF superfamily member 14 (TNFSF14), MIF macrophage migration inhibitory factor, MIP-3α macrophage inflammatory protein-3, OPN osteopontin, OPG osteoprotegerin, PlGF placental growth factor, TGF-β2 transforming growth factor beta 2, TGF-β3 transforming growth factor beta 3, TIMP-1 tissue inhibitor of metalloproteinases 1, TIMP-2 tissue inhibitor of metalloproteinases 2