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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration

Fig. 7

Macrophage and cytokine analyses after DPPSC injection in dystrophic Sgcb-null Rag2-null γc-null mice. a-d Immunofluorescence analysis for macrophage-specific F4/80 (red; a, c) and proangiogenic M2 macrophage-specific CD206 (green; b, d) in control (a, b) or DPPSC-injected (c, d) Sgcb-null Rag2-null γc-null muscles. Scale bars: 50 μm. e Quantitative analysis of the number of cells expressing F4/80 and CD206 macrophage markers per mm2 of tissue in Sgcb-null Rag2-null γc-null muscles. *p < 0.05, n = 4 for each group. f Representative images of cytokine antibody arrays showing the increase in spot intensity in IL-9 and IL-10 in DPPSC-injected (lower panel) compared to control (upper panel) Sgcb-null Rag2-null γc-null muscles. g, h Quantitative analysis of the increase in spot intensity (arbitrary units) in IL-9 (g) and IL-10 (h) in Sgcb-null Rag2-null γc-null muscles. *p < 0.05, n = 3 for each group. For e, g, h, two-tailed Student’s t test was used and results are displayed as mean ± s.e.m

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