From: Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration
Wound revascularisation, epidermal and dermal healing at day 11 | PBS | DPPSC | ||
---|---|---|---|---|
Revascularisation | Number of CD31+ vessels/mm2 tissue | 461 ± 49 | 409 ± 42 | |
mm2 CD31+ vessels/mm2 tissue | 0.07 ± 0.01 | 0.08 ± 0.02 | ||
αSMA-coated vessels vs CD31+ vessels (%) | 51 ± 5 | 66 ± 4* | ||
mm2 αSMA-coated vessels/mm2 tissue | 0.04 ± 0.01 | 0.06 ± 0.01* | ||
RBC leakage | High | Low | ||
Laminin (%) | 4.1 ± 1.0 | 4.8 ± 1.0 | ||
Epidermal healing | Mice with complete epithelial coverage (%) | 40 | 100 | |
Epithelial coverage (%) | 82 ± 10 | 100 ± 0 | ||
Epithelial thickness (μm) | 56 ± 4 | 33 ± 3** | ||
Dermal healing | Total collagen (%) | wound centre | 47 ± 4 | 61 ± 1** |
wound margin | 60 ± 4 | 61 ± 2 | ||
Organised collagen (%) | wound centre | 23 ± 3 | 38 ± 3** | |
wound margin | 35 ± 1 | 37 ± 2 | ||
Collagen type III (%) | wound centre | 27 ± 5 | 12 ± 3* | |
Collagen type I (%) | wound centre | 20 ± 5 | 39 ± 6* | |
tGFP+ αSMA+ cells not associated to vessels (%) | 0 ± 0 | 1.3 ± 0.7 |