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Table 1 Effects of DPPSC treatment in the wound healing assay

From: Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration

Wound revascularisation, epidermal and dermal healing at day 11 PBS DPPSC
Revascularisation Number of CD31+ vessels/mm2 tissue 461 ± 49 409 ± 42
mm2 CD31+ vessels/mm2 tissue 0.07 ± 0.01 0.08 ± 0.02
αSMA-coated vessels vs CD31+ vessels (%) 51 ± 5 66 ± 4*
mm2 αSMA-coated vessels/mm2 tissue 0.04 ± 0.01 0.06 ± 0.01*
RBC leakage High Low
Laminin (%) 4.1 ± 1.0 4.8 ± 1.0
Epidermal healing Mice with complete epithelial coverage (%) 40 100
Epithelial coverage (%) 82 ± 10 100 ± 0
Epithelial thickness (μm) 56 ± 4 33 ± 3**
Dermal healing Total collagen (%) wound centre 47 ± 4 61 ± 1**
wound margin 60 ± 4 61 ± 2
Organised collagen (%) wound centre 23 ± 3 38 ± 3**
wound margin 35 ± 1 37 ± 2
Collagen type III (%) wound centre 27 ± 5 12 ± 3*
Collagen type I (%) wound centre 20 ± 5 39 ± 6*
tGFP+ αSMA+ cells not associated to vessels (%)   0 ± 0 1.3 ± 0.7
  1. DPPSC dental pulp pluripotent-like stem cells, αSMA α-smooth muscle actin, RBC red blood cell, tGFP turbo green fluorescent protein
  2. *p < 0.05, **p < 0.01 vs PBS treatment, n = 5 animals/group. Results are displayed as mean ± s.e.m.