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Table 1 Effects of DPPSC treatment in the wound healing assay

From: Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration

Wound revascularisation, epidermal and dermal healing at day 11

PBS

DPPSC

Revascularisation

Number of CD31+ vessels/mm2 tissue

461 ± 49

409 ± 42

mm2 CD31+ vessels/mm2 tissue

0.07 ± 0.01

0.08 ± 0.02

αSMA-coated vessels vs CD31+ vessels (%)

51 ± 5

66 ± 4*

mm2 αSMA-coated vessels/mm2 tissue

0.04 ± 0.01

0.06 ± 0.01*

RBC leakage

High

Low

Laminin (%)

4.1 ± 1.0

4.8 ± 1.0

Epidermal healing

Mice with complete epithelial coverage (%)

40

100

Epithelial coverage (%)

82 ± 10

100 ± 0

Epithelial thickness (μm)

56 ± 4

33 ± 3**

Dermal healing

Total collagen (%)

wound centre

47 ± 4

61 ± 1**

wound margin

60 ± 4

61 ± 2

Organised collagen (%)

wound centre

23 ± 3

38 ± 3**

wound margin

35 ± 1

37 ± 2

Collagen type III (%)

wound centre

27 ± 5

12 ± 3*

Collagen type I (%)

wound centre

20 ± 5

39 ± 6*

tGFP+ αSMA+ cells not associated to vessels (%)

 

0 ± 0

1.3 ± 0.7

  1. DPPSC dental pulp pluripotent-like stem cells, αSMA α-smooth muscle actin, RBC red blood cell, tGFP turbo green fluorescent protein
  2. *p < 0.05, **p < 0.01 vs PBS treatment, n = 5 animals/group. Results are displayed as mean ± s.e.m.