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Table 4 Markers of oxidative stress in patients with limb salvage after BM-MNC application (n = 37)

From: Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia

Parameter of oxidative stress Baseline 3-month follow-up 6-month follow-up p*
Markers of endogenous antioxidant capacity
 SOD (U/L) 168 ± 50 178 ± 48 218 ± 37 0.002
 GSH (μmol/L) 7.0 ± 3.1 8.8 ± 6.3 8.7 ± 4.2 0.02
 Apo(a) (g/L) 0.26 ± 0.16 0.28 ± 0.17 0.33 ± 0.19 0.03
 Retinol (μmol/L) 2.6 ± 0.9 2.4 ± 0.66 2.3 ± 0.7 0.01
 Coenzyme Q10 (μg/L) 468 ± 182 594 ± 248 598 ± 283 0.02
 Vitamin C (μmol/L) 22 ± 15 26 ± 16 29 ± 20 0.09
 Vitamin C/Vitamin E 1.2 ± 0.9 1.4 ± 1 1.7 ± 1.4 0.07
 FRAP (μmol/L) 951 ± 645 866 ± 235 845 ± 170 0.1
 TAS (U/ml) 1.5 ± 0.3 1.5 ± 0.2 1.5 ± 0.2 0.2
 Oxystat (μmol/L) 775 ± 563 885 ± 720 959 ± 796 0.1
Markers of oxidative stress damage
 PC (μmol/L) 131 ± 32 117 ± 30 106 ± 19 0.004
 MDA (μmol/L) 1.1 ± 0.5 1.0 ± 0.6 1.1 ± 0.6 0.39
 oxLDL (U/L) 23.4 ± 7.7 28.2 ± 17 25.9 ± 8.0 0.1
 DNA fragmentation (AU) 59 ± 32 54 ± 22 54 ± 19 0.24
  1. *Baseline versus 6-month follow-up
  2. Apo(a) apolipoprotein A, BM-MNC bone marrow-derived mononuclear cell, FRAP ferric reducing ability of plasma, GSH reduced glutathione, MDA malondialdehyde, oxLDL oxidized low-density lipoproteins, Oxystat total peroxide concentration of plasma, PC protein carbonyls, SOD superoxide dismutase, TAS total antioxidant status