|
Parameter of oxidative stress
|
Baseline
|
3-month follow-up
|
6-month follow-up
|
p*
|
|---|
|
Markers of endogenous antioxidant capacity
|
|
SOD (U/L)
|
168 ± 50
|
178 ± 48
|
218 ± 37
|
0.002
|
|
GSH (μmol/L)
|
7.0 ± 3.1
|
8.8 ± 6.3
|
8.7 ± 4.2
|
0.02
|
|
Apo(a) (g/L)
|
0.26 ± 0.16
|
0.28 ± 0.17
|
0.33 ± 0.19
|
0.03
|
|
Retinol (μmol/L)
|
2.6 ± 0.9
|
2.4 ± 0.66
|
2.3 ± 0.7
|
0.01
|
|
Coenzyme Q10 (μg/L)
|
468 ± 182
|
594 ± 248
|
598 ± 283
|
0.02
|
|
Vitamin C (μmol/L)
|
22 ± 15
|
26 ± 16
|
29 ± 20
|
0.09
|
|
Vitamin C/Vitamin E
|
1.2 ± 0.9
|
1.4 ± 1
|
1.7 ± 1.4
|
0.07
|
|
FRAP (μmol/L)
|
951 ± 645
|
866 ± 235
|
845 ± 170
|
0.1
|
|
TAS (U/ml)
|
1.5 ± 0.3
|
1.5 ± 0.2
|
1.5 ± 0.2
|
0.2
|
|
Oxystat (μmol/L)
|
775 ± 563
|
885 ± 720
|
959 ± 796
|
0.1
|
|
Markers of oxidative stress damage
|
|
PC (μmol/L)
|
131 ± 32
|
117 ± 30
|
106 ± 19
|
0.004
|
|
MDA (μmol/L)
|
1.1 ± 0.5
|
1.0 ± 0.6
|
1.1 ± 0.6
|
0.39
|
|
oxLDL (U/L)
|
23.4 ± 7.7
|
28.2 ± 17
|
25.9 ± 8.0
|
0.1
|
|
DNA fragmentation (AU)
|
59 ± 32
|
54 ± 22
|
54 ± 19
|
0.24
|
-
*Baseline versus 6-month follow-up
-
Apo(a) apolipoprotein A, BM-MNC bone marrow-derived mononuclear cell, FRAP ferric reducing ability of plasma, GSH reduced glutathione, MDA malondialdehyde, oxLDL oxidized low-density lipoproteins, Oxystat total peroxide concentration of plasma, PC protein carbonyls, SOD superoxide dismutase, TAS total antioxidant status
