Culturing and transcriptome profiling of progenitor-like colonies derived from adult mouse pancreas

Table 1 Reported functions of the most significantly changed miRNAs

miRNA	Up/downregulated	Fold change (log₂)	Function	Reference
miR-31-5p	Upregulated	10.19	Regulating migration of PDAC	[34]
miR-21a-5p	Upregulated	7.89	Regulating pancreatic progenitors in chicken^a	[35]
miR-155-5p	Upregulated	7.80	Biomarker in PDAC	[36]
miR-217-5p	Downregulated	–9.10	Reduced in mouse model of PDAC	[37]
miR-802-5p	Downregulated	–6.81	Targeting HNF1B	[38]
miR-375-3p^b	Downregulated	–6.66	Promotes beta pancreatic differentiation in hiPS	[40]

PDAC pancreatic ductal adenocarcinoma, hiPS human induced pluripotent stem cells
These miRNAs were among the most significantly changed. They have been reported to be important in regulation of either pancreatic progenitors or pancreatic ductal adenocarcinoma
^ammu-miR-21a-5p is homologous to gga-miR-21 in chicken
^bPrevious ID of mmu-miR-375-3p is “mmu-miR-375”

ISSN: 1757-6512