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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

Fig. 5

Direct effects of exosomes on primary chondrocyte phenotype maintenance in the presence of IL-1β. a Expression of Col II (green) and ADAMTS5 (red) by primary chondrocytes treated with exosomes. Scale bar, 40 μm. b Percentages of the Col II-positive cells with/without the addition of exosomes and immunofluorescence intensity of ADAMTS5 with/without the addition of exosomes. c Colocalization of exosomes (red), Col II (green) and chondrocytes (blue nuclei). Scale bars, 10 μm. d Expression of Col II and ADAMTS5 by the primary chondrocytes upon addition of different concentrations of exosomes. COL II collagen type II, IL-1β, interleukin 1 beta

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