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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis

Fig. 3

Ovarian weight and structure. a Ovarian structure at 45 days after injection in the normal group, with the observation of follicles at different developmental stages and corpora lutea. b Ovarian structure at 45 days after injection in the model group, with a dramatic reduction in follicle counts. c Ovarian structure at 45 days after injection in the miR-21 group, with an increase in follicle counts as compared with the model group. d Ovarian structure at 45 days after injection in the mesenchymal stem cell (MSC) group, with an increase in follicle counts as compared with the model group but comparable to that in the miR-21 group. e Ovarian structure at 45 days after injection in the miR-21-MSC group, with an increase in follicle counts as compared with the miR-21 group and MSC group. f Ovarian weight at 15, 30, 45, and 60 days after injection in each group. *P < 0.05, compared to the miR-21 group and the MSC group

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