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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats

Fig. 2

The immunomodulatory effect of SHED on BV-2 microglia. a The co-culture system of SHED and BV-2 microglia. In a transwell system, SHED and BV-2 microglia were cultured together, as shown. b Inhibitory effect of SHED on the production of nitrite. BV-2 were treated with 1 μg/ml LPS for 24 h and then followed by SHED co-culture. The content of nitrite was measured by Griess assay. c, d The effect of SHED on pro-inflammatory cytokines TNF-α and IL-6. An ELISA assay was performed. # P < 0.05 compared with nonactivated microglia cells. * P < 0.05, ** P < 0.01 compared with LPS-only treated cells. IL-6 interleukin-6, LPS lipopolysaccharide, SHED stem cells from human exfoliated deciduous teeth, TNF-α tumor necrosis factor alpha

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