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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats

Fig. 4

SHED-Ex displays a robust response to pro-inflammatory stimuli. a Griess assay for the microglia production of nitrite with different concentrations of SHED-Ex. b ELISA assay for pro-inflammatory cytokines TNF-α and IL-6 with different concentrations of SHED-Ex. c Flow cytometry for the expression levels of CD11b and CD68 of microglia with different concentrations of SHED-Ex. d Immunofluorescence staining and confocal analysis for CD68. # P < 0.05 compared with non-activated microglia cells. * P < 0.05, ** P < 0.01, *** P < 0.001 compared with LPS-only treated cells. IL-6 interleukin-6, LPS lipopolysaccharide, TNF-α tumor necrosis factor alpha

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