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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats

Fig. 6

SHED-Ex promotes functional motor recovery after TBI. a Establishment of the TBI model in rats. b Motor assessment. The Basso, Beattie, and Bresnahan (BBB) scores for each group from 1 to 21 days after TBI. c Lesion reconstruction at 48 h and 2 weeks post-transplant. Scale bar = 50 μm (d) CD68 staining for activated microglia at 48 h and 2 weeks post-transplant. Scale bar = 50 μm. (e) Treatment with SHED-Ex significantly reduces the number of CD68+ microglia in the brains of rats after TBI. # P < 0.05 compared with sham group. *** P < 0.001 compared with TBI group. SHED-Ex stem cells from human exfoliated deciduous teeth-originated exosomes, TBI traumatic brain injury

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