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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: pIL6-TRAIL-engineered umbilical cord mesenchymal/stromal stem cells are highly cytotoxic for myeloma cells both in vitro and in vivo

Fig. 5

Ex vivo immunohistochemical detection of MM cell apoptosis. a Hematoxylin–eosin staining of tibia sections in mice xenografted IT shows the plasma cell bone expansion. As can be seen, U-266 cells are accumulated within resorptive lacunae where they appear strictly to the resorbed bone. b Immunostaining of active caspase-3 showed a high extent of apoptosis in tibiae sections of mice injected systemically with pIL6-TRAIL + -GFP +-UC-MSCs after 12 and 48 h. Active caspase-3 was undetectable in control mice treated with GFP +-UC-MSCs. GFP green fluorescent protein, MSC mesenchymal/stromal stem cell, pIL6 interleukin-6 promoter, TRAIL tumor necrosis factor related apoptosis inducing ligand, UC umbilical cord

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