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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients

Fig. 2

Transplantation of retinal progenitor cells (RPCs) repopulated the RCS rat outer nuclear layer and increased electroretinal function. a Distribution of the transplanted cells (arrows) in the subretinal space at 6 weeks after xenotransplantation indicated by DiI staining. Horizontal cellular migration could be visualized. b RPCs stained with anti-human mitochondria were seen in the outer nuclear layer (ONL), some cells were double-labeled recoverin. In addition, the ganglion cell layer (GCL) and inner nuclear layer (INL) were also marked in the host retina. b’ Enlarged area reflecting the differentiation of transplanted cells. c,c’ RPCs were double-labeled with anti-human mitochondria and rhodopsin. d Mean and standard deviation measurements of the ONL thickness in the RPC-grafted area were significantly higher compared to the control group (P < 0.05). e Representative electroretinography (ERG) (5 dB flash under scotopic conditions) recorded at 3 and 6 weeks after cell transplantation. f Mean b-wave amplitude peaks were significantly higher in transplanted animals compared to phosphate-buffered saline (PBS) controls at 3 and 6 weeks after cell transplantation (P < 0.05). Scale bars = 50 μm (b,c), 10 μm (b’,c’)

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