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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cells microvesicles stabilize endothelial barrier function partly mediated by hepatocyte growth factor (HGF)

Fig. 4

MSC-MVs reduced endothelial cell permeability via HGF. The results showed that treatment with MSC-MVs reduced hypoxia-induced endothelial paracellular and transcelluar permeability. However, the effect of treatment with MSC-MVs was significantly reduced after HGF gene knockdown. a The effect of MSC, MSC-MVs, and siHGF-MSC-MVs on relative endothelial paracellular permeability. b The effect of MSC, MSC-MVs, and siHGF-MSC-MVs on relative transcellular permeability. (n = 3, *p < 0.05, **p < 0.01 vs. control group; # p < 0.05 vs. LPS group; &p < 0.05 vs. MSC group). HGF hepatocyte growth factor, LPS lipopolysaccharide, MSC-CM mesenchymal stem cells conditioned medium, MSC-MVs mesenchymal stem cells microvesicles, MSCs, mesenchymal stem cells

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Stem Cell Research & Therapy

ISSN: 1757-6512